ND: |
ME09080302 |
PMID: |
9080302 |
LR: |
20061115 |
CED: |
19970626 |
DCO: |
19970626 |
Autoren: |
Bond A; Alavi A; Axford JS; Bourke BE; Bruckner FE; Kerr MA; Maxwell JD; Tweed KJ; Weldon MJ; Youinou P; Hay FC |
Titel: |
A detailed lectin analysis of IgG glycosylation, demonstrating disease specific changes in terminal galactose and N-acetylglucosamine. |
Quelle: |
Journal of autoimmunity; VOL: 10 (1); p. 77-85 /199702/ |
PM: |
Print |
SU: |
IM |
Sprache: |
English |
CY: |
ENGLAND |
JID: |
8812164 |
ISSN: |
0896-8411 |
CO: |
JOAUEP |
Institution: |
Division of Immunology, St George's Hospital Medical School, London. a.bond@sghms.ac.uk |
DT: |
Journal Article; Research Support, Non-U.S. Gov't |
Schlagwörter |
CT: |
ACETYLGLUCOSAMINE/*metabolism; ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID/immunology; ARTHRITIS, RHEUMATOID/metabolism; GALACTOSE/*metabolism; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G/*metabolism; LECTINS/metabolism; MIDDLE AGED; OLIGOSACCHARIDES/metabolism; SJOGREN'S SYNDROME/immunology; SJOGREN'S SYNDROME/metabolism |
CTG: |
ACETYLGLUCOSAMIN/*Stoffwechsel; ERWACHSENER; ALTE MENSCHEN; ALTE MENSCHEN, 80 JAHRE UND ÄLTER; ARTHRITIS, RHEUMATOIDE/Immunologie; ARTHRITIS, RHEUMATOIDE/Stoffwechsel; GALACTOSE/*Stoffwechsel; GLYCOSYLIERUNG; MENSCH; IMMUNGLOBULIN G/*Stoffwechsel; LECTINE/Stoffwechsel; MENSCHEN IM MITTLEREN LEBENSALTER; OLIGOSACCHARIDE/Stoffwechsel; SJÖGREN-SYNDROM/Immunologie; SJÖGREN-SYNDROM/Stoffwechsel |
TE: |
Immunoglobulin G; Lectins; Oligosaccharides; Galactose/26566-61-0; Acetylglucosamine/7512-17-6 |
CR: |
26566-61-0; 7512-17-6 |
AB: |
Serum IgG from rheumatoid arthritis patients contains a decreased number of oligosaccharide structures ending in galactose and thus there is an increase in N-acetylglucosamine as the terminal sugar, compared with healthy individuals. The relationship between these two sugars varies depending on the disease examined: IgG from patients with rheumatoid arthritis, juvenile onset chronic arthritis and Crohn's disease are at one extreme, and exhibit a reciprocal galactose:N-acetylglucosamine relationship, while Sjögren's syndrome and osteoarthritis IgG are at the other extreme, exhibiting a parallel increase in the expression of both galactose and N-acetylglucosamine. These results may occur as a consequence of more than one glycosylation site which is differentially glycosylated, but more likely by changes in the level of bisecting N-acetylglucosamine. |