ND: |
ME16514823 |
PMID: |
16514823 |
LR: |
20061115 |
CED: |
20060306 |
DCO: |
20060323 |
Autoren: |
Svetlova MS; Ignat'ev VK |
Titel: |
Experience with glucosamine hydrochloride in the treatment of patients with osteoarthrosis |
Quelle: |
Terapevticheskii arkhiv; VOL: 77 (12); p. 64-7 /2005/ |
PM: |
Print |
SU: |
IM |
Sprache: |
Russian |
CY: |
Russia (Federation) |
JID: |
2984818R |
ISSN: |
0040-3660 |
CO: |
TEARAI |
DT: |
Comparative Study; English Abstract; Journal Article |
Schlagwörter |
CT: |
FEMALE; FOLLOW-UP STUDIES; GLUCOSAMINE/*therapeutic use; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/physiopathology; PAIN MEASUREMENT; RANGE OF MOTION, ARTICULAR/drug effects; TREATMENT OUTCOME |
CTG: |
WEIBLICH; VERLAUFSSTUDIEN; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; MÄNNLICH; MENSCHEN IM MITTLEREN LEBENSALTER; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/Pathophysiologie; SCHMERZMESSUNG; BEREICH DER GELENKBEWEGLICHKEIT/Arzneimittelwirkungen; BEHANDLUNGSERGEBNIS |
TE: |
Glucosamine/3416-24-8 |
CR: |
3416-24-8 |
AB: |
AIM: To study efficacy and tolerance of glucosamine hydrochloride (GH) in osteoarthrosis (OA). MATERIAL AND METHODS: GH was given to patients of the study group (n = 30) for 2 months in a dose 1200 mg/day, while diclofenak was administered to the patients from the control group (n = 24) in a dose 100 mg/day. Clinical, laboratory activity of the disease was estimated before the study, after it, 3 and 6 months later. Side effects were also studied. The efficacy of GH therapy was estimated according to the Lequesne's index, pain intensity on vision-analogy scale (VAS), doses of non-steroidal anti-inflammatory drugs during the day. RESULTS: A decrease in the Lequesne's index and pain by VAS while walking, requirements of NSAIDs in OA patients were revealed. No unfavorable aftereffects of GH were observed. CONCLUSION: GH relieves pain, improves function of the affected joints, reduces necessity in NSAIDs. The effect persists for 3 months. No side effects were registered. |