ND: |
ME15747611 |
PMID: |
15747611 |
LR: |
20051117 |
CED: |
20050307 |
DCO: |
20050621 |
Autoren: |
Baker CL Jr; Ferguson CM |
Titel: |
Future treatment of osteoarthritis. |
Quelle: |
Orthopedics; VOL: 28 (2 Suppl); p. s227-34 /200502/ |
PM: |
Print |
SU: |
IM |
Sprache: |
English |
CY: |
United States |
JID: |
7806107 |
ISSN: |
0147-7447 |
CO: |
ORTHDK |
Institution: |
Hughston Clinic, PC, Columbus, Ga, USA. |
DT: |
Journal Article; Review |
RN: |
55 |
Schlagwörter |
CT: |
ADJUVANTS, IMMUNOLOGIC/pharmacokinetics; ADJUVANTS, IMMUNOLOGIC/therapeutic use; ANTHRAQUINONES/therapeutic use; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL/therapeutic use; CAMELLIA SINENSIS; CARTILAGE, ARTICULAR/transplantation; CHONDROCYTES/transplantation; CHONDROITIN/therapeutic use; FORECASTING; GENE THERAPY; GLUCOSAMINE/therapeutic use; HUMANS; HYALURONIC ACID/pharmacokinetics; HYALURONIC ACID/therapeutic use; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/surgery; PHYTOTHERAPY; PLANT EXTRACTS/therapeutic use |
CTG: |
ADJUVANZIEN, IMMUNOLOGISCHE/Pharmakokinetik; ADJUVANZIEN, IMMUNOLOGISCHE/therapeutische Anwendung; ANTHRACHINONE/therapeutische Anwendung; ANTIPHLOGISTIKA, NICHTSTEROIDALE/therapeutische Anwendung; CAMELLIA SINENSIS; KNORPEL, GELENK-/Transplantation; CHONDROZYTEN/Transplantation; CHONDROITIN/therapeutische Anwendung; VORHERSAGE; GENTHERAPIE; GLUCOSAMIN/therapeutische Anwendung; MENSCH; HYALURONSÄURE/Pharmakokinetik; HYALURONSÄURE/therapeutische Anwendung; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/Chirurgie; PHYTOTHERAPIE; PFLANZENEXTRAKTE/therapeutische Anwendung |
TE: |
Adjuvants, Immunologic; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Plant Extracts; green tea extract AR25; diacetylrhein/13739-02-1; Glucosamine/3416-24-8; Hyaluronic Acid/9004-61-9; Chondroitin/9007-27-6 |
CR: |
13739-02-1; 3416-24-8; 9004-61-9; 9007-27-6 |
AB: |
Osteoarthritis represents an advanced stage of disease progression caused in part by injury, loss of cartilage structure and function, and an imbalance in inflammatory and noninflammatory pathways. The burden of this disease will increase in direct proportion to the increase in the older adult population. Research on current and experimental treatment protocols are reviewed, including the effect of hyaluronic acid in both in vitro and in vivo studies, autologous chondrocyte and osteochondral plug implantation, and gene therapy. Disease-modifying osteoarthritis drugs and in vivo studies of glucosamine and chondroitin sulfate are reviewed. |