ND: |
ME10838710 |
PMID: |
10838710 |
LR: |
20061115 |
CED: |
20000801 |
DCO: |
20000801 |
Autoren: |
Menzel EJ |
Titel: |
Polymeres Chondroitinsulfat versus monomeres Glukosamin zur Behandlung der Arthrose. Polymeric chondroitin sulfate vs. monomeric glucosamine for the treatment of osteoarthritis |
Quelle: |
Wiener medizinische Wochenschrift (1946); VOL: 150 (5); p. 87-90 /2000/ |
PM: |
Print |
SU: |
IM |
Sprache: |
German |
CY: |
AUSTRIA |
JID: |
8708475 |
ISSN: |
0043-5341 |
CO: |
WMWOA4 |
Institution: |
Institut für Immunologie, Universität Wien. ernst.johannes.menzel@univic.ac.at |
DT: |
English Abstract; Journal Article; Review |
RN: |
12 |
Schlagwörter |
CT: |
AGGRECANS; CHONDROITIN SULFATES/*metabolism; CHONDROITIN SULFATES/*therapeutic use; EXTRACELLULAR MATRIX PROTEINS/*; GLUCOSAMINE/*metabolism; GLUCOSAMINE/*therapeutic use; HUMANS; LECTINS, C-TYPE; MENISCI, TIBIAL/metabolism; MENISCI, TIBIAL/radionuclide imaging; OSTEOARTHRITIS/*drug therapy; OSTEOARTHRITIS/*metabolism; OSTEOARTHRITIS/radionuclide imaging; PROTEOCHONDROITIN SULFATES/metabolism; PROTEOGLYCANS/metabolism; RADIOPHARMACEUTICALS/diagnostic use; SODIUM PERTECHNETATE TC 99M/diagnostic use; SYNOVIAL FLUID/metabolism; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON |
CTG: |
AGGREKANE; CHONDROITINSULFATE/*Stoffwechsel; CHONDROITINSULFATE/*therapeutische Anwendung; EXTRAZELLULÄRE MATRIXPROTEINE/*; GLUCOSAMIN/*Stoffwechsel; GLUCOSAMIN/*therapeutische Anwendung; MENSCH; LECTINE, C-TYP-; MENISKEN, KNIEGELENK-/Stoffwechsel; MENISKEN, KNIEGELENK-/Szintigraphie; OSTEOARTHROSE/*Arzneimitteltherapie; OSTEOARTHROSE/*Stoffwechsel; OSTEOARTHROSE/Szintigraphie; PROTEOCHONDROITIN-SULFATE/Stoffwechsel; PROTEOGLYCANE/Stoffwechsel; RADIOPHARMAKA/diagnostische Verwendung; NATRIUMPERTECHNETAT TC 99M/diagnostische Verwendung; SYNOVIALFLÜSSIGKEIT/Stoffwechsel; EINZELPHOTONEN-EMISSIONSCOMPUTERTOMOGRAPHIE |
TE: |
Aggrecans; Extracellular Matrix Proteins; Lectins, C-Type; Proteochondroitin Sulfates; Proteoglycans; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m/23288-60-0; Glucosamine/3416-24-8; Chondroitin Sulfates/9007-28-7 |
CR: |
23288-60-0; 3416-24-8; 9007-28-7 |
AB: |
Two potentially chondro-protective substances are compared with each other: polymeric chondroitin sulfate and monomeric glucosamine. Chondroitin-sulfate is characterized by tropism for cartilage, i.e. it is preferentially incorporated into cartilagenous tissue. This quality could be of interest in the SPECT-analysis of osteoarthritic knee joints. In contrast to the classic agents Ibuprofen and Indomethacin, the antiinflammatory action of chondroitin-sulfate is less prominent, but the drug does not show any toxic side effects. Glucosamine on the other hand is a multifunctional precursor of the glycosaminoglycan synthesis in general. It lacks the cartilage tropism of chondroitin-sulfate. Into what sort of a glycosaminoglycan glucosamine is eventually integrated, depends therefore on the nature of the cells participating in the biosynthesis. |