ND: |
ME16818461 |
PMID: |
16818461 |
CED: |
20070123 |
Autoren: |
Biggee BA; Blinn CM; Nuite M; Silbert JE; McAlindon TE |
Titel: |
Effects of oral glucosamine sulphate on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis. |
Quelle: |
Annals of the rheumatic diseases; VOL: 66 (2); p. 260-2 /200702/ |
PM: |
Print-Electronic |
EPD: |
20060703 |
SU: |
IM |
Sprache: |
English |
CY: |
England |
JID: |
0372355 |
ISSN: |
0003-4967 |
CO: |
ARDIAO |
Institution: |
Division of Rheumatology, Tufts New England Medical Center, Boston, Massachusetts, USA. |
DT: |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
NG: |
M01-RR00054 RR NCRR; T-32 PHS |
AB: |
BACKGROUND: and objective: Glucosamine is suggested to affect glucose transport and insulin resistance. The effects of oral glucosamine on serum glucose and insulin levels at the initiation and throughout the duration of a 3-h oral glucose tolerance test were examined. METHODS: Sera from 16 patients with osteoarthritis, but with no other diagnosed medical condition who had fasted overnight, were obtained every 15-30 min during the 3 h of continued fasting and during the 3 h after ingestion of 75 g of glucose with or without ingestion of 1500 mg of glucosamine sulphate. Glucose was analysed by high-performance liquid chromatography using a Metrohm-Peak 817 Bioscan, and the area under the curve (AUC) for glucose was calculated. Insulin was measured by radioimmunoassay every 30 min for 2 h. RESULTS: Three participants who were found to have previously undiagnosed abnormalities of glucose tolerance demonstrated significant (p = 0.04) incremental elevations in glucose levels after ingestion of glucosamine sulphate. The other 13 participants also had mean incremental elevations that were not significant (p = 0.20). Glucosamine sulphate ingestion had no effect on insulin levels. CONCLUSION: The results suggest that glucosamine ingestion may affect glucose levels and consequent glucose uptake in patients who have untreated diabetes or glucose intolerance. |